Dr. Brian Searle
Relevant Experience
2021 – Present
Assistant Professor, Biomedical Informatics Dept , Ohio State University – Columbus, OH
Member of the Pelotonia Institute for Immuno-Oncology (PIIO) at the OSUCCC – James
2016 – Present
Chairman of the Board of Directors, Proteome Software Inc. – Portland, OR
Primary focus on scientific direction and long-term planning.
2004 – 2016
Founder and Principal Scientist, Proteome Software Inc. – Portland, OR
Lead bioinformatician and supervisor for the research and development team.
2001 – 2004
Research Assistant II, Pediatrics Dept, Oregon Health & Science University – Portland, OR
1998 – 2001
Research Assistant, Physiology Dept, Dartmouth Medical School – Lebanon, NH
Assistant Professor, Biomedical Informatics Dept , Ohio State University – Columbus, OH
Member of the Pelotonia Institute for Immuno-Oncology (PIIO) at the OSUCCC – James
2016 – Present
Chairman of the Board of Directors, Proteome Software Inc. – Portland, OR
Primary focus on scientific direction and long-term planning.
2004 – 2016
Founder and Principal Scientist, Proteome Software Inc. – Portland, OR
Lead bioinformatician and supervisor for the research and development team.
2001 – 2004
Research Assistant II, Pediatrics Dept, Oregon Health & Science University – Portland, OR
1998 – 2001
Research Assistant, Physiology Dept, Dartmouth Medical School – Lebanon, NH
Education
2018 – 2021
Translational Research Fellow, Institute for Systems Biology – Seattle, WA
Independent translational postdoc fellowship, including salary and research funding
2014 – 2018
PhD in Genome Sciences, MacCoss Lab, University of Washington – Seattle, WA
NIH Ruth L. Kirschstein NRSA Predoctoral Fellow (F31)
Dissertation: “Development of Data Independent Acquisition Methods to Systematically
Analyze the Human Proteome”
1997 – 2001
BA in Chemistry, Glasfeld Lab, Reed College – Portland, OR
Experiment-based thesis: “Glycerol-Based Nucleoside Analogs: The synthesis of 3-
(alkoxymethyl)pyrimidines and their implications for the prebiotic world”
Translational Research Fellow, Institute for Systems Biology – Seattle, WA
Independent translational postdoc fellowship, including salary and research funding
2014 – 2018
PhD in Genome Sciences, MacCoss Lab, University of Washington – Seattle, WA
NIH Ruth L. Kirschstein NRSA Predoctoral Fellow (F31)
Dissertation: “Development of Data Independent Acquisition Methods to Systematically
Analyze the Human Proteome”
1997 – 2001
BA in Chemistry, Glasfeld Lab, Reed College – Portland, OR
Experiment-based thesis: “Glycerol-Based Nucleoside Analogs: The synthesis of 3-
(alkoxymethyl)pyrimidines and their implications for the prebiotic world”
Recent publication highlight
Journal of Proteome Research, 2023*†
Searle BC, Shannon AE, Wilburn DB.
Scribe: Next Generation Library Searching for DDA Experiments. J Proteome Res. 2023 Feb 3;22(2):482-490.
Searle BC, Shannon AE, Wilburn DB.
Scribe: Next Generation Library Searching for DDA Experiments. J Proteome Res. 2023 Feb 3;22(2):482-490.
Awards & honors
2022 Journal of the American Society for Mass Spectrometry: Faces of Mass Spectrometry
2021 Journal of Proteome Research: Rising Stars in Proteomics and Metabolomics: 40 under 40
2020 American Society for Mass Spectrometry: Emerging Talent Award
2016 – 2018 NIH/NIGMS, F31 GM119273 (NRSA Individual Predoctoral Fellowship):
Awarded for “Methods to elucidate quantitative phosphorylation dynamics in the IGF-1 signaling pathway”
2016 NSF Graduate Research Fellowship Program (GRFP): Honorable Mention
2021 Journal of Proteome Research: Rising Stars in Proteomics and Metabolomics: 40 under 40
2020 American Society for Mass Spectrometry: Emerging Talent Award
2016 – 2018 NIH/NIGMS, F31 GM119273 (NRSA Individual Predoctoral Fellowship):
Awarded for “Methods to elucidate quantitative phosphorylation dynamics in the IGF-1 signaling pathway”
2016 NSF Graduate Research Fellowship Program (GRFP): Honorable Mention
Service and Committee Membership
Committee and Research Group Membership
Proteomics Standards Research Group (sPRG), Association of Biomolecular Research Facilities (ABRF):
Member (June 2013 – current); Co-chair (March 2018 – April 2019)
Board of Directors, American Society for Mass Spectrometry (ASMS): Member at Large for Digital
Communications (June 2014 – June 2016)
Education Committee, ABRF: Member (July 2010 – March 2014)
Bioinformatics for Mass Spectrometry Interest Group, ASMS: Co-chair (September 2010 – June 2013)
Proteome Informatics Research Group (iPRG), ABRF: Co-founder; Member (March 2006 – March 2010);
Chair (February 2008 – February 2009)
Proteomics Standards Research Group (sPRG), Association of Biomolecular Research Facilities (ABRF):
Member (June 2013 – current); Co-chair (March 2018 – April 2019)
Board of Directors, American Society for Mass Spectrometry (ASMS): Member at Large for Digital
Communications (June 2014 – June 2016)
Education Committee, ABRF: Member (July 2010 – March 2014)
Bioinformatics for Mass Spectrometry Interest Group, ASMS: Co-chair (September 2010 – June 2013)
Proteome Informatics Research Group (iPRG), ABRF: Co-founder; Member (March 2006 – March 2010);
Chair (February 2008 – February 2009)
Society Membership
ASMS American Society for Mass Spectrometry, 2005 - present
ABRF Association of Biomolecular Research Facilities, 2006 - present
HUPO Human Proteome Organization, 2019 - present
ASMS American Society for Mass Spectrometry, 2005 - present
ABRF Association of Biomolecular Research Facilities, 2006 - present
HUPO Human Proteome Organization, 2019 - present
Scientific Service
Coordinated and chaired scientific sessions at ASMS (2011, 2013, 2020) and ABRF (2012, 2018, 2020)
Coordinated workshop/roundtable sessions at US-HUPO (2020, 2021), ASMS (2011, 2012, 2013), and ABRF
(2010, 2014)
Peer-reviewed manuscripts for Molecular & Cellular Proteomics, Journal of Proteome Research, Proteomics,
Journal of the American Society for Mass Spectrometry, Journal of Mass Spectrometry, Analytical Chemistry,
Bioinformatics, BMC Bioinformatics, Nature Biotechnology, Nature Methods, and Nature Communications
Reviewed programs/abstracts for ASMS in 2012 and 2022, ABRF from 2011 to 2014
Served as consultant to the NIH Common Fund Glycoscience Program 2020 to 2021
Coordinated and chaired scientific sessions at ASMS (2011, 2013, 2020) and ABRF (2012, 2018, 2020)
Coordinated workshop/roundtable sessions at US-HUPO (2020, 2021), ASMS (2011, 2012, 2013), and ABRF
(2010, 2014)
Peer-reviewed manuscripts for Molecular & Cellular Proteomics, Journal of Proteome Research, Proteomics,
Journal of the American Society for Mass Spectrometry, Journal of Mass Spectrometry, Analytical Chemistry,
Bioinformatics, BMC Bioinformatics, Nature Biotechnology, Nature Methods, and Nature Communications
Reviewed programs/abstracts for ASMS in 2012 and 2022, ABRF from 2011 to 2014
Served as consultant to the NIH Common Fund Glycoscience Program 2020 to 2021
Corporate Scientific Advisory Boards
2012 – Present
Board of Directors for Proteome Software
2021 – Present
Scientific Advisory Board Member for Talus Biosciences
2021 – 2023
Scientific Advisory Board Member of the Integrated Proteomics Group for Bruker Daltonics GmbH
2012 – Present
Board of Directors for Proteome Software
2021 – Present
Scientific Advisory Board Member for Talus Biosciences
2021 – 2023
Scientific Advisory Board Member of the Integrated Proteomics Group for Bruker Daltonics GmbH