YUE Chen, pHD
Assistant professor at University of Minnesota
Dr. Chen completed his PhD training under the guidance of Dr. Yingming Zhao at UT Southwestern Medical Center in Dallas, Texas. Working in the field of biological mass spectrometry, Yue participated in the first global analysis of lysine acetylation proteome using affinity enrichment and discovered two short-chain acylations, lysine propionylation and butyrylation, as novel protein modifications and histone epigenetic marks. To better identify novel posttranslational modifications, Yue developed an unrestrictive database search engine termed PTMap. Application of PTMap by Zhao lab at the University of Chicago has led to the discovery of other short-chain acylations including crotonylation, succinylation and hydroxybutyrylations. As part of his postdoctoral research, Yue applied quantitative proteomics analysis to globally identify Sirt1-mediated lysine acetylation targets and Sirt5-dependent lysine succinylation proteome. In 2013 Yue established his own lab at the University of Minnesota. Yue’s independent research focuses on proteomic characterization of oxygen-sensing modification pathways in neuronal development and cancer. His lab also develops quantitative chemical proteomic technology for site-specific stoichiometric analysis of acetylation and ubiquitination.